|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
White adipose tissue (WAT) is the primary energy storage organ and its excess contributes to obesity, while brown adipose tissue (BAT) and inducible thermogenic (beige/brite) adipocytes in WAT dissipate energy via Ucp1 to maintain body temperature.
|
29704660 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We suggest a role for UCP-1 polymorphism in the pathogenesis of obesity and arteriosclerosis.
|
11341297 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity.
|
9054939 |
1997 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether or not the UCP1 -3826 A>G polymorphism is associated with obesity and related metabolic disorders in grade III obese patients.
|
26458326 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals.
|
12565902 |
2003 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other mechanism can substitute for UCP1 in mediating diet-induced adrenergic thermogenesis, and that UCP1 activity can be determinative for obesity development in mice and possibly in humans.
|
19187776 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein (UCP) genes, which may contribute to energy metabolism in mitochondria, may be involved in the pathogenesis of obesity.
|
23412863 |
2013 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To study associations of UCP gene expression with human obesity, we determined, by a competitive reverse transcription-polymerase chain reaction assay, UCP mRNA expression levels in intra- and extraperitoneal adipose tissues of 79 obese subjects and 17 lean controls.
|
9374134 |
1997 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate mitochondrial respiratory capacity, mitochondrial content, and UCP1 gene expression in white adipose tissue from women with obesity before and after the physical training program.
|
31282585 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our results demonstrate that the development of glucocorticoid-induced obesity is not caused by a decreased UCP1-dependent thermogenic capacity.
|
31067456 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus UCP1-dependent diet-induced thermogenesis limits obesity development during exposure to obesogenic diets but does not prevent obesity as such.
|
28679625 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This work provides evidences that BML-260 can also exert a JSP-1-independent effect in activating UCP1 and thermogenesis in adipocytes, and be potentially applied to treat obesity.
|
31281493 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study links the GG homozygous form of UCP1 with obesity and blood pressure among females only.
|
22764640 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study examined the possible association of the β3-AR and UCP1 polymorphisms with overweight/obesity or lipid variation in a Southwest Chinese population.
|
25928572 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review summarizes data supporting the existence of brown adipocytes and the role of UCP1 in energy dissipation in adult humans, and the genetic variety association with the fat metabolism, obesity and diabetes.
|
19444646 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results reveal a role for Egr1 in blocking energy expenditure via direct Ucp1 transcription repression and highlight Egr1 as a therapeutic target for counteracting obesity.
|
29170465 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicate that soluble DPP-4 inhibits β-adrenoreceptor-stimulated UCP1 induction and that chronic DPP-4 inhibitor treatment may prevent obesity through the activation of BAT function.
|
30410858 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that LFBE decreased obesity partly by increasing the BAT mass and the energy expenditure by activating BAT thermogenesis and WAT browning in a UCP1-dependent mechanism.
|
31488234 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These processes were correlated with the increased gene expression of Dio2 and Ucp-1, which represents brown adipose tissue (BAT) activation, in both WD-induced atherosclerosis and high-fat-induced obesity models.
|
31570705 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings suggested that the mechanism of BF against obesity was at least partially through increasing gene expression of PGC-1α and UCP1 for energy consumption in BAT and inhibiting inflammation in WAT.
|
27473963 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, several studies investigating the role of polymorphisms in the gene encoding UCP1 in susceptibility to obesity or metabolic syndrome have been performed.
|
28100847 |
2016 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There were no significant differences in mRNA levels of uncoupling protein-1 or F4/80 in brown AT (BAT) or of several intestinal integrity markers in colon suggesting that the protection against obesity is not due to excessive BAT or to impaired intestinal absorption of fat.
|
30860940 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The uncoupling protein (UCP) gene is one of the genes known to have a strong association with obesity and insulin resistance.
|
21584501 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The stimulation of NRF-1, TFam, UCP-1 and the enhanced activity of mitochondrial complex IV may be associated with remedying obesity.
|
17397829 |
2007 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The seasonal increase in abdominal SC WAT UCP1 mRNA was considerably diminished in subjects with a BMI > 30 kg/m(2), suggesting that dysfunctional WAT in obesity inhibits adipose thermogenesis.
|
25299843 |
2014 |